(PK) profile. Herein, further lead optimization of H-Phe-Phe-NH2 by substituting the N-terminal phenylalanine for a benzylcarbamate group giving a new type of SP1-7 analogues with good binding affinities is reported. Exploration and Pharmacokinetic Profiling of Phenylalanine Based Carbamates as Novel Substance P 17 Analogues by, rebecca Fransson, Per Artursson, Anna Carlsson-jonsson, and, mathias Hallberg, aCS Medicinal Chemistry Letters, 2014, the bioactive metabolite of Substance P, the heptapeptide SP1-7 more. Company, search type, search type, search. First name, last name, birth name, where? Please enter a search string of at least 2 characters. (1 - 5 from 5 ) sorted by relevance / date, advanced Search, save as document n a iin platinum, member. Siteye tklayarak veya giderek, Facebook'ta ve Facebook'un dnda çerezler araclyla bilgi toplamamza izin vermi olursunuz.
Swedish University dissertations (essays) about marianne carlsson.
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University dissertation from Uppsala : Acta Universitatis Upsaliensis.
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Extensive in vitro as well as in vivo PK characterization is presented for this compound. Phone., hobby, attribute. Evaluation of different C-terminal functional groups,.e., hydroxamic acid, acyl sulfonamide, acyl cyanamide, acyl hydrazine, and oxadiazole, suggested hydroxamic acid as a bioisosteric replacement for the original primary amide. Aiming at the development of drug-like SP1-7 peptidomimetics we have previously reported on the discovery of H-Phe-Phe-NH2 as a high affinity lead compound. Wir verwenden Cookies, um Inhalte zu personalisieren, Werbeanzeigen maßzuschneidern und zu messen sowie die Sicherheit unserer Nutzer zu erhöhen. The bioactive metabolite of Substance P, the heptapeptide SP1-7 has been shown to attenuate signs of hyperalgesia in diabetic mice, which indicate a possible use of compounds targeting the SP1-7 binding site as analgesics for neuropathic pain. Çerikleri kiiselletirmemize, reklamlar özelletirip ölçmemize ve daha güvenli bir deneyim salamamza yardmc olmas için çerezleri kullanrz. Yararlanabileceiniz kontroller ve daha fazlas hakknda bilgi aln: Çerezler lkesi. Weitere Informationen zu unseren Cookies und dazu, wie du die Kontrolle darüber behältst, findest du hier: Cookie-Richtlinie. Join Facebook to connect with Marianne Carlsson and others you may know. People named Marianne Carlsson. Find your friends on Facebook.
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